African Haplogroup M1 is related to Japanese Haplogroup D – By Dr. Clyde Winters

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Haplogroup M1 is related to the D haplogroups.

M1 transitions are found in many Asian M haplogroups (Fucharoen et al., 2001; Yao et al., 2002) For example researchers have found that the Tanzanian M1 haplogroup cluster with people from Oceania (Gonder et al., 2006).

Researchers have found that the Tanzanian M1 haplogroup cluster with people from Oceania (Gonder et al., 2006). And, as mentioned earlier the M1 mutations 16129, 16189, 16249 and 16311 are found in many southeast and East Asian haplogroups (Fucharoen et al., 2001; Yao et al., 2002).

Haplotypes with HVSI transitions defining 16129- 16223-16249-16278-16311-16362; and 16129-16223-16234-16249-16211-16362 have been found in Thailand and among the Han Chinese (Fucharoen et al., 2001; Yao et al., 2002) and these were originally thought to be members of Haplogroup M1. However, on the basis of currently available FGS sequences, carriers of these markers have been found to be in the D4a branch of Haplogroup D, the most widespread branch of M 1 in East Asia (Fucharoen et al., 2001; Yao et al., 2002).

The transitions 16129, 16189, 16249 and 16311 are known to be recurrent in various branches of Haplogroup M, especially M1 and D4.

References:
Fucharoen, G., S. Fucharoen and S. Horai, 2001. Mitochondrial DNA polymorphism in Thailand. J.
Hum. Genet., 46: 115-125.

Gonder, M.K., H.M. Mortensen, F.A. Reed, A. de Sousa and S.A. Tishkoff, 2006. Whole mtDNA genome
sequence analysis of ancient African lineages. Mol. Biol. Evol., 24(3): 757-768.

Yao, Y.G., Q.P. Kong, H.J. Bandelt, T. Kivisild and Y.P. Zhang, 2002. Phylogeographic differentiation
of mitochondrial DNA in Han chinese. Am. J. Hum. Genet., 70: 635-651.


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