Cannabinoids as antioxidants and neuroprotectants – United States Patent: 6,630,507

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United States Patent: 6,630,507

Cannabinoids as antioxidants and neuroprotectants


Cannabinoids have been found to have antioxidant properties, unrelated to NMDA receptor antagonism. This new found property makes cannabinoids useful in the treatment and prophylaxis of wide variety of oxidation associated diseases, such as ischemic, age-related, inflammatory and autoimmune diseases.

The cannabinoids are found to have particular application as neuroprotectants, for example in limiting neurological damage following ischemic insults, such as stroke and trauma, or in the treatment of neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease and HIV dementia.


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Inventors: Hampson; Aidan J. (Irvine, CA), Axelrod; Julius (Rockville, MD), Grimaldi; Maurizio (Bethesda, MD)

Assignee: The United States of America as represented by the Department of Health and Human Services (Washington, DC)

Appl. No.: 09/674,028

Filed: February 2, 2001

PCT Filed: April 21, 1999

PCT No.: PCT/US99/08769

PCT Pub. No.: WO99/53917

PCT Pub. Date: October 28, 1999

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